en
In recent years, interest in the commensal intestinal microbes living in our gut has increased significantly. These microbes are not just passive residents of our digestive tract; they play a crucial role in host physiology, particularly in maintaining immune homeostasis and supporting the functions of the nervous system.
A research team led by Dr Ronchi at the Institute of Microbiology and Infection Immunology (I-MIDI) at Charité – Universitätsmedizin Berlin is dedicated to exploring these fascinating microbes and their diverse functions. This research focuses not only on identifying the various bacterial species present in our gut but also on understanding their functional properties. By cultivating these microbes in vitro or ex vivo, Dr Ronchi's team can investigate their ability to produce specific metabolites that are important for host health.
The use of a Whitley Anaerobic Workstation, which allows for the cultivation of different intestinal bacteria under controlled conditions, is a central element of the teams research. Samples are taken from both preclinical mouse models and human specimens, providing an opportunity to study microbes in a relevant context and observe their responses to different conditions. The Whitley A45 Workstation, utilised by, Dr Ronchi, Andrina Rutsch, Johna B Kantsjö, and Matteo Ceccon, has three ports for convenient user access to the entire incubation and working areas, and accommodates up to 780 x 90mm Petri dishes.
A particular focus is placed on examining the microbes under inflammatory conditions, especially in neuroimmune inflammatory states. These inflammations can have significant impacts on host health and disrupt the balance of the gut microbiota. By understanding the interactions between microbes and the immune system, new approaches for the treatment and prevention of diseases can be developed.
Overall, the research conducted offers an exciting insight into the world of microbiota and their role in human health. It will be intriguing to see what findings the research team uncovers and how these may contribute to improving therapeutic strategies in the future.
We wish the team great success in their future research.
If you are interested in learning more about the Whitley anaerobic product range view our brochure by clicking the button below, or for further information email us at sales@dwscientific.co.uk.
English